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PolyBLOCK / 자동멀티합성장치
  • 4 또는 8 개의 개별 반응 영역
  • 개별적인 온도 제어 (온도 간격 100 °C, -40 °C에서 +200 °C까지의 온도 범위)
  • 개별적인 교반 제어 (250에서 1500 rpm, 중력 및 오버헤드 교반 가능)
  • Compact design 일반적인 실험노트북보다 크기가 크지 않음.
  • 하나의 플랫폼에서 반응 용기의 어떤 조합이든 사용 가능
  • 직관적인 제어 소프트웨어와 다양한 인터페이스 선택 가능

연구실 생산성을 극대화하도록 디자인된 PolyBLOCK과의 병렬 합성 기술은 사용하기 쉽고 유연하며 소형 다기능 반응기 시스템입니다.

PolyBLOCK 4(4개의 독립적으로 제어되고 모니터링되는 영역) 또는 PolyBLOCK 8(8개의 독립적으로 제어되고 모니터링되는 영역)을 사용하면 PolyBLOCK 4는 최대 500 ml의 작업 용적을 제공하며 PolyBLOCK 8은 최대 120 ml까지 제공합니다. 반응 용기 옵션은 1 ml의 HPLC 시험관에서 250 ml의 라운드 또는 플랫 바텀 플라스크 및 500 ml까지의 사용자 정의 반응 용기까지 다양합니다. 각 영역의 교반은 독립적으로 제어되며 반응기 및/또는 영역 온도로 온도 모니터링 및 제어가 제공됩니다.

Features and Options

Temperature Control
실온부터 200 °C까지 (외부 circulat 없이 소프트웨어 제한). -40 °C까지 범위를 줄이는 옵션(순환기에 따라 다름). 각 반응기 주위에 별도의 맨틀이 있어 반응기 간에 100 °C 이상의 범위/차이로 온도를 개별적으로 제어할 수 있음.
Independent Stirring
자석 교반 막대를 사용한 간접 교반이 기본 기능으로 제공됨. Small Scale 및 낮은 점도 샘플에 대해서도 효율적인 기계 교반이 가능. 대형 용기에 대한 선택적인 직접 교반도 가능.
Intelligent Software Control and Analysis
제어 소프트웨어는 정기적인 데이터 기록, multi-step 레시피, 매개 변수 제어 및 피드백 루프
Safety Features
사용자 안전을 보장하기 위해 자동으로 구성 가능한 반응 감지 및 종료 절차가 포함됨. 모든 시스템에는 자동 하드웨어 및 소프트웨어 fail-safes 가 설치됨.
Condensing Options
대형 반응기에서 응축 및 inert를 위한 간편한 Quick connect solution. 밀봉으로 냉각액 유출 없이 condenser를 제거할 수 있음. 또한 회절 및 inerting 블록, 시험관, 튜브 및 반응기에 대한 어댑터가 있는 reflux 옵션도 제공됨.
Reactor Options
Glass, Stainless Steel또는 Hastelloy 재질의 용기 유형 사용 가능. 반응기 용적은 최대 500 ml까지. 고압 및 진공 시스템 사용 가능, 고압 시스템에 대한 자세한 내용은 PolyBLOCK 고압에서 확인 가능. 활성 펌프, 수동 딥 튜브, 자동 레벨 제어 또는 ASU와 같은 다중 샘플링 장치를 통한 샘플링 시스템. 완전 자동화된 액체 및 가스 공급 및 체적 주사 펌프를 통한 시약 추가. 이러한 솔루션은 고압 및 저압 시스템에 모두 적용 가능. 제어 옵션 모든 관련 입력이 기록될 수 있어 반응기 시스템의 자동 모니터링 및 필요한 경우 피드백 제어가 가능함. 센서 옵션 온도, 압력, pH, 탁도, 전도도. 원격 FTIR, 입자 크기 프로브 및 Raman 프로브와 같은 타사 프로브의 통합이 가능함.

Technical Literature

The following is a list of supporting Technical Literature.

Publications

The following are a list of some technical publications which highlight the use of the equipment.

Structural analysis of metastable pharmaceutical loratadine form II, by 3D electron diffraction and DFT+D energy minimisation

Grahame R. Woollam, *a Partha P. Das, *b Enrico Mugnaioli, c Iryna Andrusenko, c Athanassios S. Galanis,b Jacco van de Streek, d Stavros Nicolopoulos,b Mauro Gemmi c and Trixie Wagnere 01-Oct-2020

https://doi.org/10.1039/D0CE01216E (Subscription or purchase maybe required for full access)
Structural analysis of metastable pharmaceutical loratadine form II, by 3D electron diffraction and DFT+D energy minimisation

Grahame R. Woollam, *a Partha P. Das, *b Enrico Mugnaioli, c Iryna Andrusenko, c Athanassios S. Galanis,b Jacco van de Streek, d Stavros Nicolopoulos,b Mauro Gemmi c and Trixie Wagnere
01-Oct-2020

https://doi.org/10.1039/D0CE01216E(Subscription or purchase maybe required for full access)
https://doi.org/10.1016/j.cej.2020.126688(Subscription or purchase maybe required for full access)
Enantioselective Synthesis of a γ-Secretase Modulator via Vinylogous Dynamic Kinetic Resolution

Neil A. Strotman,* Antonio Ramirez, Eric M. Simmons, Omid Soltani, Andrew T. Parsons, Yu Fan, James R. Sawyer, Thorsten Rosner, Jacob M. Janey, Kristy Tran, Jun Li, Thomas E. La Cruz,Charles Pathirana, Alicia T. Ng, and Joerg Deerberg
13-Aug-2018

https://doi.org/10.1021/acs.joc.8b01734(Subscription or purchase maybe required for full access)
Formation mechanism of aroma compounds in a glutathione-glucose reaction with fat or oxidized fat

J. Zhao, T. Wang, J. Xie, Q. Xiao, J. Cheng, F. Chen, S. Wang and B. Sun,
01-Jul-2018

https://doi.org/10.1016/j.foodchem.2018.07.106(Subscription or purchase maybe required for full access)
Influence of Process Parameters on the Heterogeneous Nucleation of Active Pharmaceutical Ingredients onto Excipients

R. Arribas Bueno, C. Crowley, B. Hodnett, S. Hudson and P. Davern, Org. Process. Res. Dev., 2017, 21, 559-570.
01-Mar-2017

https://doi.org/10.1021/acs.oprd.6b00425(Subscription or purchase maybe required for full access)
Synthesis, characterization and performance of bifunctional catalysts for the synthesis of menthol from citronellal

J. Dam, A. Ramanathan, K. Djanashvili, F. Kapteijn and U. Hanefeld, RSC Adv., 2017, 7, 12041-12053.
20-Feb-2017

https://doi.org/10.1039/C6RA25931F(Subscription or purchase maybe required for full access)
One-pot combination of enzyme and Pd nanoparticle catalysis for the synthesis of enantiomerically pure 1,2-amino alcohols

J. Schrittwieser, F. Coccia, S. Kara, B. Grischek, W. Kroutil, N. d'Alessandro and F. Hollmann, Green Chem., 2013, 15, 3318.
01-Sep-2013

https://doi.org/10.1039/C3GC41666F(Subscription or purchase maybe required for full access)
Use of food-grade proteases to recover umami protein–peptide mixtures from rice middlings

Lucia Bagnasco, Valeria M.Pappalardo, Andrea Meregaglia, Thammarat Kaewmanee, Daniela Ubiali, Giovanna Speranzabe. M. Elisabetta Cosulich
01-Jan-2013

https://doi.org/10.1016/j.foodres.2012.11.007(Subscription or purchase maybe required for full access)
Investigation of the Solid-State Polymorphic Transformations of Piracetam

Anthony Maher,*,† Colin C. Seaton,† Sarah Hudson,†,‡ Denise M. Croker,† Åke C. Rasmuson,† and Benjamin K. Hodnett†
05-Nov-2012

https://doi.org/10.1021/cg301418c(Subscription or purchase maybe required for full access)
https://doi.org/10.1021/je3006453(Subscription or purchase maybe required for full access)
Solid−Liquid Equilibrium of D- and L-Tartaric Acid and Their Importance for Enantioseparation

Xiaofang Wang,† Xiangyang Zhang,† Simon Black,‡ Leping Dang,*,† and Hongyuan Wei†
11-May-2012

https://doi.org/10.1021/je300170y(Subscription or purchase maybe required for full access)
Mixed-level supersaturated design application to a robustness study on an organic synthesis

Alice Croguennoc, Marc Frédéric, Magalie Claeys-Bruno, Roger Phan-Tan-Luu, Michelle Sergent
01-Apr-2012

https://doi.org/10.1016/j.chemolab.2012.01.005(Subscription or purchase maybe required for full access)
Understanding the p-Toluenesulfonamide/Triphenylphosphine Oxide Crystal Chemistry: A New 1:1 Cocrystal and Ternary Phase Diagram

Denise M. Croker,*,†,§ Michael E. Foreman,†,‡ Bridget N. Hogan,†,§ Nuala M. Maguire,†,‡ Curtis J. Elcoate,†,‡ Benjamin K. Hodnett,†,§ Anita R. Maguire,†,∥ Åke C. Rasmuson,†,§ and Simon E. Lawrence†,‡
15-Dec-2011

https://doi.org/10.1021/cg201300e(Subscription or purchase maybe required for full access)
https://doi.org/10.1016/j.jcrysgro.2010.05.043(Subscription or purchase maybe required for full access)

Testimonials

AutoLAB
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My experience with HEL dates since 2005. During these years HEL was the provider of the most important lab equipment with the help of which I developed many different API pharmaceutical processes in the companies l worked for including Merck, Pfizer, and Theravance. The versatility of the automated lab reactors (AutoLAB), the ease of use of and the accuracy of the TSu and Simular systems, as well as the flexibility of the PolyBLOCK made my work much easier and accurate. I would like to mention the great relationship I established with the service engineers and the sales people at HEL. With their help I was able to customize the software and the hardware of the equipment to our specific needs. This readiness to accommodate each customer’s specific needs gives HEL the edge over their competitors and makes them the preferred vendor for pharmaceutical lab equipment.

Theravance Inc – USA
PolyBLOCK
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With the polyblock 4 system significant time savings have been achieved compared to using conventional laboratory reactors while at the same time obtaining more information on the process studied. The system has given reproducible process control making it very useful in DOE experiments on a precise recrystallisation where variations due to operational error had to be minimised. Also with the flexibility in reactor size the process was run on smaller scale than previously reducing the demand for a valuable process intermediate.

Almac Group – United Kingdom
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A versatile time saving tool for QBD & DOE study for all kind of chemistry, crystallization, & even integrated with Calorimetric study. HEL motto “Better Chemistry – Faster” matches with output of instrument giving better control over chemistry & faster result. Thanks for making our work simple.

Cipla – India
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We purchased a PolyBLOCK 4 zone system in November of 2012 and the system was delivered on time and to our specification. The PolyBLOCK has increased throughput by allowing us to easily and efficiently run multiple reactions. Our system has proven to be very reliable and we utilize it on a daily basis. We are very satisfied with our purchase of the PolyBLOCK 4 and the advice and technical support offered by HEL. start

Secant Medical – USA
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PolyBlock PB4 is ideal and best suited for Pharmaceutical application in terms of flexibility, upgradability for various applications like pH monitoring and control, solubility and MSZW for crystallisation , high Pressure Hydrogenation , Online Real Time calorimetry, reflux & inerting , PAT tools in future , overhead motor stirring , extended temperature range -80 to 250 ( depends on the chiller being used with the PB4 ).

Dr D.Y. Patil - Institute of Pharmaceutical Sciences – India

The PolyBLOCK 4 is simple to use for all chemists and biochemists in our company. It allows us to carry out more reactions at a time, under very good temperature control. We also operate the PolyBlock overnight under pre-programmed procedures, to save a lot of precious time. We use different sizes of glassware in the same block, which allows us to investigate our chemistry at small scale, and then scale-up using the same equipment and pre-programmed procedure.

BioCompatibles UK Ltd – United Kingdom
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HEL’s PolyBLOCK is a classic invention that allows process development at the fastest rate. We have developed a process for 9 steps carbohydrate project in just 45 days with the help of PolyBLOCK

Dr Nikhil Jadhav - Aarti Industries